The brain has been discovered through multiple significant moments in imaging technologies and experimental strategies. In most cases, the resulting images were irresistible as visual artifacts, seemingly legible to any audience, while their interpretation turned out, over time, to be vastly more complex. This is as true for historical as well as contemporary research. In response, we will design an exhibit around specific moments in brain science, its techniques and the resulting imagery, considering both data-oriented approaches as well as purely visual, potentially artful expressions. We have partnered with neuroscientists to surface the knowledge embedded in this imagery and the ways in which they change over time. We will produce a series of visualizations that could potentially become part of the content of a permanent exhibit design in the Mind and Brain Institute the first building under construction on Columbia's Manhattanville Campus.